Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births

Uterine abnormalities infertility can be treated with implantable patches for tension-free healing. However, the existing clinical are still limited in effective uterus recovery, resulting low pregnancy and live birth rates. Herein, a novel engineered, biocompatible Janus collagen patch (JCOP) is developed to achieve excellent uterine defect recovery increase births. The JCOP highly match structure, micromorphology, mechanical properties of natural due homologous-like tissue homogeneity. JCOP's rough surface loose-extracellular-matrix-like porosity promote fibroblast adhesion regeneration, whereas its smooth reduces prevents visceral adhesions. Additionally, it exhibits exceptional resistance swelling deformation along stable strength long-term preservation body withstand highest pressure humid interior environment attributed superior structural layout. Moreover, [email protected], functional linked basic growth factor (bFGF) via specific collagen-binding domain, significantly promotes repair injured uterus, restores ability endometrium accept embryos, supports their development viable stage rat model damage. This study shows great promise treating caused by